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Some of the cases resulted in fatality and many of the intentional overdoses were with multiple drugs including CNS depressants.
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Assessments were made at 1, 2, 3 and 6 hours after treatment.
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Tizanidine metabolites are not known to be active; their half-lives range from 20 to 40 hours.
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The dose can be repeated at 6 to 8 hour intervals, as needed, to a maximum of three doses in 24 hours.
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A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
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